The Advisory Committee on the Medical Uses of Isotopes (ACMUI) advises the U.S. Nuclear Regulatory Commission (NRC) on policy and technical issues that arise in the regulation of the medical uses of radioactive material in diagnosis and therapy. The ACMUI's recommendations and comments to the NRC come through formal reports submitted by Subcommittees. Below is a list of Subcommittees, including their charges, members, established dates, deactivated dates, and any final, draft or interim reports. Subcommittee reports may also be found on the Subcommittee Reports Web Page.
On this page:
Active ACMUI Subcommittees
| Subcommittee Name | Subcommittee Charge |
Subcommittee Members | Status |
|---|---|---|---|
| Subcommittee on Radiopharmaceutical Production and Distribution Safety | Review and comment on emerging radiation safety concerns related to radiopharmaceutical production, distribution, and associated impurities. The subcommittee will assess whether these issues warrant NRC actions, including potential updates to guidance or regulatory framework. | Richard Green (Chair) Dr. Hossein Jadvar Dr. Joanna Fair Dr. Michael Folkert Dr. Richard Harvey Josh Mailman Staff Resource: Dan Shaw |
Subcommittee Established 4/21/26 |
| Subcommittee on Reducing Barriers to Medical Use Licensing Rulemaking | ACMUI review and comments on the subcommittee on reducing barriers to medical use licensing rulemaking. |
Megan Shober Staff Resource: Katie Tapp |
Subcommittee Established 11/21/25 |
| Subcommittee on Membership of an Interventional Radiologist | To assess ACMUI membership to determine if the ACMUI would like to propose to the Commission a change in membership to include an interventional radiologist | Dr. Andrew Einstein, Chair Dr. Hossein Jadvar Dr. Michael Folkert Ms. Rebecca Allen Dr. Richard Harvey NRC staff resource: Dr. Katie Tapp |
Subcommittee established 4/8/24 Report(s) Available: |
| Subcommittee on Emerging Medical Technologies/Rubidium-82 Generator Rulemaking | To review and comment on the staff’s regulatory basis for the Emerging Medical Technologies/Rubidium-82 Generator rulemaking. | Ms. Megan Shober, Chair Dr. Ronald Ennis Dr. Harvey Wolkov Dr. Richard Harvey Dr. Hossein Jadvar Non-voting subcommittee consultant: Dr. John F. Angle NRC staff resource: Ms. Maryann Ayoade |
Subcommittee established 08/18/22 |
| Subcommittee on Potential AI Deep Learning Applications for NRC Medical Enterprise | The Subcommittee is tasked with exploring and evaluating the potential applications of artificial intelligence (AI) and deep learning technologies to enhance the efficiency and effectiveness of the Nuclear Regulatory Commission's (NRC) medical staff and ACMUI. | Dr. Andrew Einstein, Chair Dr. Joanna Fair Dr. Michael Folkert Mr. Josh Mailman Dr. Hossein Jadvar Consultant: Dr. John F. Angle Staff Resource: Maryann Ayoade |
Subcommittee established 04/07/25 Report(s) Available: |
| Subcommittee on Giving Advice on ADVANCE Act of July 2024 Mission Statement | The subcommittee will provide recommendations and advice to support the Nuclear Regulatory Commission's (NRC) implementation of the ADVANCE Act. | Dr. Richard Harvey, Chair Dr. Michael Folkert Ms. Megan Shober Mr. Josh Mailman Dr. Hossein Jadvar Staff Resource: Katie Tapp |
Subcommittee established 04/07/25 Report(s) Available: |
| Subcommittee on Extravasations | To provide advice on including medical event reporting criteria for extravasations. *Original Charge 4/3/19: Review the U.S. Nuclear Regulatory Commission (NRC) staff’s Memorandum “Preliminary Evaluation of Radiopharmaceutical Extravasation and Medical Event Reporting” dated April 1, 2021 and provide feedback and recommendations. *Charge expanded 3/7/24: Review and provide feedback and recommendations on the NRC staff’s draft proposed rule, associated draft implementation guidance, and draft model procedures for reporting nuclear medicine injection extravasations as medical events. |
Dr. Andrew Einstein Mr. Richard Green Dr. Richard Harvey Ms. Melissa Martin, Chair Ms. Megan Shober NRC staff resource: Mr. Daniel DiMarco |
Subcommittee established on 04/03/19 |
| Subcommittee on Training and Experience Requirements for All Modalities |
To review and evaluate the training and experience requirements for all modalities in 10 CFR Part 35.
*Charge Expanded 8/6/19:
|
Dr. Michael Folkert, Chair Dr. Richard Harvey Dr. Hossein Jadvar Mr. Zoubir Ouhib Ms. Megan Shober NRC staff resource: Ms. Maryann Ayoade |
Subcommittee Report(s) Available: |
| Subcommittee on Yttrium-90 (Y-90) Microsphere Gastrointestinal (GI) Deposition | To evaluate changes in Y-90 microsphere brachytherapy practice and recent Y-90 microsphere medical events to identify potential cause of sudden increase in reported events involving unexpected GI deposition. | Dr. Richard Harvey, Chair Dr. Joanna Fair Mr. Zoubir Ouhib Dr. Michael O’Hara Dr. Michael Folkert Consultant: Dr. Fritz Angle Staff Resource: Ms. Sarah Spence |
Subcommittee established 12/17/24 |
| Subcommittee on Regulatory Guide 8.39 Release of Patients Administered Radioactive Materials |
*Charge updated 6/11/26: To review and provide comments on the proposed patient release revisions in the Reforming and Modernizing the NRC’s Radiation Protection Framework proposed rulemaking and revisions to Regulatory Guide 8.39, “Release of Patients Administered Radioactive Material.” Regulatory Guide 8.39, "Release of Patients Administered Radioactive Material". To review the revisions to Regulatory Guide 8.39, “Release of Patients Administered Radioactive Material” |
Dr. Johanna Fair (Chair) NRC staff resource: Sarah Spence |
Subcommittee established 09/21/18 |
| Subcommittee on Medical Events | To review Medical Events (MEs) to advise the Advisory Committee on the Medical Use of Isotopes (ACMUI) and United States Nuclear Regulatory Commission (NRC) about emerging trends that may need regulatory attention. |
Dr. Richard Harvey, Chair Dr. Michael Folkert Mr. Richard Green Dr. Joanna Fair Mr. Zoubir Ouhib Dr. Harvey Wolkov Consultant: Dr. Fritz Angle NRC Staff Resource: Mr. Daniel DiMarco |
Subcommittee established 3/19/15 ACMUI Medical Event Presentations can be found on NRC medical toolkit. |
Past Subcommittees
| Subcommittee Name | Subcommittee Charge |
Subcommittee Members | Status |
|---|---|---|---|
| Subcommittee on Modernizing NRC Regulations for Byproduct Material Use Rulemaking | ACMUI review and comments on the subcommittee on modernizing NRC regulations for byproduct material use rulemaking. |
Dr. Hossein Jadvar Staff Resource: Katie Tapp |
Subcommittee Established 11/14/25 Report(s) Available: Subcommittee was deactivated on 6/08/26 |
| Subcommittee on ACMUI Generic Reporting Process | The subcommittee is charged with establishing best practices for the preparation of reports, including guidance on writing subcommittee reports and developing effective presentations, including Commission presentations. | Ms. Megan Shober, Chair Dr. Harvey Wolkov Mr. Josh Mailman Mr. Richard Green Dr. Zoubir Ouhib Staff Resource: Lillian Armstead |
Subcommittee established 04/07/25 Report(s) Available: Subcommittee was deactivated on 4/20/26 |
| Subcommittee on Modernizing Requirements Relating to Physical Protection of Category 1 and Category 2 Quantities of Radioactive Material Rulemaking | ACMUI review and comments on the modernizing requirements relating to physical protection of Category 1 and Category 2 quantities of radioactive material rulemaking. |
Dr. Michael Folkert Staff Resource: Katie Tapp |
Subcommittee Established 10/21/25 Report(s) Available: Subcommittee was deactivated on 4/20/26 |
| Subcommittee on Review of Guidance on Licensing of Alpha Therapy Nuclides Memo | To review and comment on the staff's memo for licensing the use of alpha nuclides in radiopharmaceutical therapy. |
Richard Green (Chair) Dr. Hossein Jadvar |
Subcommittee established 1/20/26 Report(s) Available: Subcommittee was deactivated on 4/20/26 |
| Subcommittee on Development of a Generic Process Checklist to Help Reduce Medical Events | To consider development of process checklists to minimize medical events. | Mr. Richard Green, Chair Ms. Melissa Martin Dr. Hossein Jadvar Ms. Rebecca Allen Mr. Zoubir Ouhib Dr. Richard Harvey Staff Resource: Mr. Daniel DiMarco |
Subcommittee established 12/12/24 2025 |
| Subcommittee on Financial Assurance Requirements for Disposition of Category 1–3 Byproduct Material Radioactive Sealed Sources | To review and comment on the NRC staff’s regulatory basis document. * On April 8, 2024, the ACMUI Chair created a subcommittee to update the regulations in 10 CFR 30.35 that deal with financial assurance for Category 1 and Category 2 material. A joint NRC / Agreement State working group has drafted this document in accordance with Commission Direction. |
Richard L. Green, BS Pharm (Chair) Rebecca Allen, MS Richard Harvey, DrPH Zoubir Ouhib, MS Harvey B. Wolkov, MD NRC Staff Resource: Daniel Shaw |
Subcommittee established 4/8/2024 2024 |
| Subcommittee on ACMUI Bylaws | To provide recommendations to revise the AMCUI Bylaws in light of the Office of the Inspector General's (OIG) special inquiry with regards to the appearance of conflict of interest by members. The subcommittee should also ensure that any changes in the FACA rule are incorporated and sufficient information regarding conduct of meetings for ACMUI public meetings. | Ms. Rebecca Allen, Chair Mr. Richard Green Dr. Michael O’Hara Mr. Zoubir Ouhib Dr. Harvey Wolkov Staff Resource: Cindy Flannery |
Subcommittee established 4/8/24 Report(s) Available: Subcommittee deactivated 11/4/24 |
| Subcommittee on Akesis Galaxy RTi Draft Licensing Guidance | To review and comment on the U.S. Nuclear Regulatory Commission (NRC) staff’s draft Akesis Galaxy® RTi Licensing Guidance. | Rebecca Allen Richard Harvey PhD Zoubir Ouhib, MS Megan Shober, MS Harvey Wolkov, MD (Chair) NRC Staff Resource: Daniel Shaw |
Subcommittee was established on 12/08/23 2024 |
| Subcommittee on Yttrium-90 Microsphere Brachytherapy Eye90 Microspheres Device | To review and comment on the NRC staff’s draft licensing guidance for the ABK Biomedical, Inc. Eye90 microspheres® manual brachytherapy device for hepatocellular carcinoma. | Dr. Michael Folkert Ms. Rebecca Allen Dr. Andrew Einstein Dr. Darlene Metter Mr. Zoubir Ouhib Consultant: Dr. John Angle Staff Resource: Sarah Spence |
Subcommittee established 11/3/23 Report(s) Available: Subcommittee deactivated 4/24/24 |
| Subcommittee on Liberty Vision Y-90 Disc and iWand® Ophthalmic System | To review the Liberty Vision technology and comment on the NRC staff’s draft Liberty Vision Y-90 Eye Brachytherapy Source Licensing Guidance. |
Mr. Zoubir Ouhib (chair) Dr. Harvey Wolkov Ms. Megan Shober Dr. Michael O’Hara Ms. Rebecca Allen NRC staff resource: Ms. Maryann Ayoade |
Subcommittee established 10/04/21 Report(s) Available: Subcommittee was deactivated on 4/24/24.
|
| Subcommittee on Decommissioning Financial Assurance for Sealed and Unsealed Radioactive Materials Draft Proposed Rule | To review and comment on the draft proposed rule for the Decommissioning Financial Assurance for Sealed and Unsealed Radioactive Materials rulemaking. | Ms. Rebecca Allen Dr. Richard Harvey Dr. Hossein Jadvar Mr. Josh Mailman Ms. Melissa Martin Ms. Megan Shober Staff Resource: Cindy Flannery |
Subcommittee established 12/5/22 Report(s) Available: Subcommittee deactivated 5/17/23 |
| Subcommittee on Y-90 Medical Events | To evaluate the issue of Y-90 microspheres medical events in more depth and, in consultation with vendors, propose methods to decrease the number of Y-90 microsphere-related medical events. | Dr. Vasken Dilsizian Dr. John F. Angle, Dr. Michael O’Hara (chair) Ms. Megan Shober Mr. Josh Mailman Ms. Melissa Martin Non-voting subcommittee consultant: Dr. John F. Angle NRC staff resource: Dr. Katie Tapp |
Subcommittee was deactivated on 12/19/22. |
| Subcommittee on Alpha DaRTTM Manual Brachytherapy | To review the Alpha Dart technology and comment on the NRC staff’s draft Alpha Dart Licensing Guidance. |
Dr. Ronald Ennis (chair) Dr. Hossein Jadvar Dr. Michael O’Hara Ms. Megan Shober Ms. Becky Allen Mr. Zoubir Ouhib NRC staff resource: Dr. Katie Tapp |
Subcommittee established May 2021 Subcommittee was deactivated on 1/21/22. |
| Subcommittee on Emerging Radiopharmaceutical Therapy Knowledge Requirements in Theranostics | To outline the knowledge and specific or specialized practice or policy requirements needed for the safe use and handling of emerging radiopharmaceuticals in theranostics. | Dr. Vasken Dilsizian Dr. Ronald Ennis Dr. Hossein Jadvar (Chair) Mr. Josh Mailman Dr. Michael O’Hara Mr Zoubir Ouhib NRC staff resource: Ms. Maryann Ayoade |
Subcommittee established May 2021 Subcommittee was deactivated on 4/24/24. |
| Subcommittee on Proposed Revisions to Abnormal Occurrence Medical Event Criteria |
|
*Membership amended Chair (TBD) Dr. Ronald Ennis Dr. Hossein Jadvar Ms. Megan Shober Mr. Zoubir Ouhib NRC staff resource: Dr. Katie Tapp |
Subcommittee established 03/30/20 Subcommittee was deactivated on 9/16/21. |
| Subcommittee on Radionuclide Generator Knowledge and Practice Requirements |
|
Dr. Vasken Dilsizian Mr. Richard Green (Chair) Ms. Melissa Martin Ms. Megan Shober Dr. Harvey Wolkov NRC staff resource: Ms. Maryann Ayoade |
Subcommittee established May 2021 2021 |
| Subcommittee on ACMUI COVID-19 Impacts | To review the impacts of COVID-19 on the medical community and provide recommendations for any regulatory relief measures in the areas of nuclear medicine and radiation oncology during the COVID-19 pandemic. | Dr. Vasken Dilsizian Mr. Richard Green Dr. Hossein Jadvar (chair) Ms. Melissa Martin Ms. Megan Shober Dr. Harvey Wolkov Non-voting subcommittee consultants: Mr. Gary Bloom and Mr. Zoubir Ouhib NRC staff resource: Ms. Lisa Dimmick |
Subcommittee established 3/30/20 Subcommittee was deactivated on 5/4/20. |
| Subcommittee on an Interventional Radiologist | To investigate the need for an interventional radiologist (IR) on the ACMUI, including whether an IR should be a non-voting consultant or full ACMUI member. |
Dr. Vasken Dilsizian NRC staff resource: Dr. Katie Tapp |
Subcommittee established 9/11/19 Report(s) Available: Subcommittee was deactivated on 4/6/20.
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| Subcommittee on Patient Intervention | To evaluate the definition of patient intervention and other actions and circumstances that are exclusive of medical events. |
Dr. Vasken Dilsizian NRC staff resource: Ms. Maryann Ayoade |
Subcommittee established 9/11/19 Report(s) Available: Subcommittee was deactivated as work continued in Appropriateness of medical event reporting subcommittee. |
| Subcommittee on ACMUI Bylaws |
*Charge Amended 9/11/19: To determine (1) Should there be term limits for the ACMUI Chair and Vice Chair? If so, how long? and (2) Should the ACMUI Vice Chair automatically become the ACMUI Chair? |
*Membership Amended 9/11/19: Mr. Michael Sheetz NRC staff resource amended 9/11/19: Ms. Kellee Jamerson |
Subcommittee established 9/21/18 Subcommittee was deactivated on 4/6/20. |
| Subcommittee on Xcision GammaPod Licensing Guidance | To review the draft Xcision® GammaPod™ Licensing Guidance |
Mr. Zoubir Ouhib NRC staff resource: Dr. Katie Tapp |
Subcommittee established 5/16/19 Report(s) Available: Subcommittee was deactivated on 10/23/19. |
| Subcommittee on ACMUI Institutional Memory | To improve the ACMUI's institutional memory and provide possible recommendations for methods of tracking and/or retrieving ACMUI documents. |
Dr. Ronald Ennis NRC staff resource: Ms. Kellee Jamerson |
Subcommittee Report(s) Available: Subcommittee was deactivated on 10/23/19. |
| Subcommittee on Infiltrations and Medical Event Reporting | To review the NRC's 1980 determination related to infiltrations and medical event reporting [45 FR 31703]. |
Dr. Vasken Dilsizian NRC staff resource: Ms. Maryann Ayoade |
Subcommittee Report(s) Available: Subcommittee was deactivated on 10/23/19. |
| Subcommittee on Yttrium-90 Microspheres Brachytherapy Sources and Devices TheraSphere® and SIR_Spheres ® Licensing Guidance (Rev. 10) | To review the draft Revision 10 of the Yttrium-90 Microspheres Brachytherapy Sources and Devices TheraSphere® and SIR_Spheres ® Licensing Guidance |
Dr. Vasken Dilsizian NRC staff resource: |
Subcommittee Report(s) Available: Subcommittee was deactivated on 5/9/19. |
| Subcommittee on Regulatory Guide 8.39 Release of Patients Administered Radioactive Materials (Initial Draft) | Review the revisions to Regulatory Guide 8.39, "Release of Patients Administered Radioactive Material" *Note: Regulatory Guide 8.39 is being revised in two phases. Phase 1 updates the patient release guidance, including information for patient instructions and updates to Table 3. Phase 2 will include updates to the dosimetric equations, methodologies, and tables used to calculate dose to members of the public from released patients. |
Dr. Vasken Dilsizian NRC staff resource: |
Subcommittee Report(s) Available: |
| Subcommittee on ACMUI Bylaws | To review and update the ACMUI Bylaws, as needed, including a review of the role of the ACMUI Chair and his/her participation on subcommittees |
Dr. A. Robert Schleipman NRC staff resource: |
Subcommittee Report(s) Available: Subcommittee was deactivated on 4/10/19. |
| Subcommittee on Germanium-68/Gallium-68 Pharmacy Grade Generator Licensing Guidance (Revision 1) | To review and provide comments on the the Draft Revision 1 to the Germanium-68/Gallium-68 Pharmacy Grade Generator Licensing Guidance |
Ms. Melissa Martin NRC staff resource: |
Subcommittee Report(s) Available: Subcommittee was deactivated on 5/6/19. |
| Subcommittee on Appropriateness of Medical Event Reporting | To review the appropriateness of the required elements of medical event reporting, the adherence to these requirements, and the recommended actions to improve reporting |
Dr. Vasken Dilsizian NRC staff resource: |
Subcommittee Report(s) Available: Subcommittee was deactivated on 10/23/19 |
| Subcommittee on Nursing Mother Guidelines for the Medical Administration of Radionuclides | To review the radiation exposure from diagnostic and therapeutic radiopharmaceuticals including brachytherapy to the nursing mother and child |
Dr. Vasken Dilsizian NRC staff resource: |
Subcommittee Report(s) Available: Subcommittee was deactivated on 1/31/19. |
| Subcommittee on Physical Presence Requirements for the Leksell Gamma Knife® Icon™ |
To propose the appropriate physical presence requirements for the Leksell Gamma Knife® Icon ™ radiosurgery unit Charge Expanded 7/01/18: |
Dr. Ronald Ennis Membership Amended 7/1/18 to add: Ms. Megan Shober and Mr. Zoubir Ouhib NRC staff resource: |
Subcommittee Report(s) Available: Subcommittee deactivated on 2/27/18. |
| Subcommittee on Yttrium-90 Microsphere Brachytherapy Sources and Devices TheraSpheres and SIR-Spheres Licensing Guidance |
To provide comments on the following:
|
Mr. Frank Costello Dr. Sue Langhorst Dr. Darlene Metter (chair) Dr. Chris Palestro |
Subcommittee Report(s) Available: Subcommittee was superseded by the Draft Rev. 10 Subcommittee established on 9/21/18 |
| Subcommittee on Patient Intervention (Part II) | The new charge was to clarify Issue II (passive vs. active patient intervention) from the 10/8/15 ACMUI presentation on "Unintentional Treatment Outcome" |
Mr. Frank Costello NRC staff resource: |
Subcommittee Report(s) Available: 2017 (Final Report was incorporated as an addendum to the Medical Event Reporting and Impact on Medical Licensee Patient Safety Culture Final Report) Subcommittee |
| Subcommittee on Medical Event Reporting and Impact on Safety Culture |
The charge of the subcommittee is to:
|
Mr. Frank Costello NRC staff resource: Dr. Katie Tapp |
Subcommittee Report(s) Available: Subcommittee deactivated on 9/11/17. |
| Subcommittee on Medical Event Reporting for All Modalities Except for Permanent Implant Brachytherapy | To propose appropriate criteria for Medical Event Reporting for events other than permanent implant brachytherapy |
Dr. Vasken Dilsizian NRC staff resource: Membership Amended 10/6/16: Dr. Pat Zanzonico stepped down from the subcommittee. Mr. Frank Costello was appointed to the subcommittee. |
Subcommittee Report(s) Available: Subcommittee was deactivated on 4/27/17 |
| Subcommittee on Training and Experience for Authorized Users of Alpha and Beta Emitters | To evaluate if the required 700 hours for training and experience for authorized users of alpha and beta emitters places hardship on the patient community. If so, the subcommittee should make recommendations for potential changes (rulemaking). | Dr. Vasken Dilsizian Dr. Ronald Ennis Dr. Sue Langhorst Dr. Chris Palestro (Chair) Ms. Laura Weil Dr. Pat Zanzonico |
Subcommittee Report(s) Available: Subcommittee |
| Subcommittee on Radioactive Seed Localization for Non-Palpable Lesions Licensing Guidance | To review the existing 10 CFR 35.1000 licensing guidance for radioactive seed localization and make recommendations for revisions to the guidance |
Dr. Philip Alderson NRC staff resource: |
Subcommittee Report(s) Available: Subcommittee deactivated on 6/24/16. |
| Subcommittee on Patient Intervention | To review and evaluate the phrase "patient intervention" |
Dr. Alderson NRC staff resource: |
Subcommittee No formal report provided. Patient Intervention Subcommittee Subcommittee was re-established on 10/6/16.
|
| Subcommittee on Germanium-68 (Ge-68) Decommissioning Funding Plan (DFP) |
To evaluate the cost of a decommissioning funding plan (DFP) for the use of Ge-68, its effect on the future clinical use of new Charge amended 3/19/15:
|
Mr. Frank Costello Dr. Sue Langhorst Mr. Mattmuller (chair) Dr. Chris Palestro Dr. Pat Zanzonico. |
Subcommittee established 5/8/14 Report(s) Available: Subcommittee deactivated 7/29/16 when exemption memo was issued |
| Subcommittee on Advanced Notice for Proposed Rulemaking for 10 CFR Part 20 | To review the advanced notice of proposed rulemaking for Title 10 Code of Federal Regulations Part 20, "Standards for Protection Against Radiation" | Mr. Frank Costello Dr. Vasken Dilsizian Dr. Sue Langhorst (chair) Mr. Mattmuller Dr. Pat Zanzonico |
Subcommittee established 9/30/14 Report(s) Available: Subcommittee deactivated 1/29/15 |
| Subcommittee on Medical Event Reporting Criteria of the Yttrium-90 Microspheres (35.1000) Guidance | To review the medical event reporting criteria of the yttrium-90 microspheres (35.100) guidance and recommend any changes. | Mr. Frank Costello Dr. Milton Guiberteau (chair) Dr. Sue Langhorst Dr. Chris Palestro Dr. Bruce Thomadsen Dr. James Welsh |
Subcommittee Report(s) Available: Subcommittee deactivated 9/29/14 |
| Subcommittee on NRC Medical Use Policy Statement |
To determine if the Policy Statement needed revision(s). In addition, the subcommittee was asked to address the following two questions:
|
Dr. Philip Alderson Dr. Milton Guiberteau Dr. Chris Palestro Dr. John Suh Dr. Bruce Thomadsen (chair) |
Subcommittee Report(s) Available: Subcommittee deactivated 12/5/14 when the Commission agreed not to update the Medical Policy Statement at this time |